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Tender Details
- Country: Italy
- Summary: Implementation of a Multi-Omics Workflow to Derive Human Reference Points and Health-Based Guidance Values (Hbgvs) from Quantitative in Vitro Data
- ITT Ref No: 79505463
- Deadline: 22 May 2023
- Competition: ICB
- Financier: European Food Safety Authority (EFSA)
- Purchaser Ownership: Public
- Tender Value: 3000000.00
- Notice Type: Tender
- Document Ref. No.: 120969-2023
- Purchaser's Detail :
- Description :
- The overarching goal of the project is to define, validate and apply a standardised workflow (experimental and computational) for deriving reliable human reference points and health-based guidance values (HBGVs) using cutting edge in-vitro approaches, namely organ-on-chip (OoC) platforms and multiple OMICs endpoints (transcriptomics, metabolomics, and epigenomics). The newly generated data will be used to develop and train a bioinformatics pipeline suitable to predict mechanistic information such as mode of action (MoA), adverse outcome pathways (AOP), key biomarkers, in-vivo reference points (using IVIVE-PBK modelling) and health-based guidance values (HBGV). In phase two, the experimental and bioinformatics workflow, defined and tested in phase one, will be used to predict the aforementioned reference points and mechanistic information for a new set of emerging hazardous substances or substances with positive health claims related to food and feed.
Doc Title: Implementation of a Multi-OMICs Workflow to Derive Human Reference Points and Health-based Guidance Values (HBGVs) from Quantitative in Vitro Data
Contract Type: Services - Documents :
Purchaser : EUROPEAN FOOD SAFETY AUTHORITY (EFSA)
Address : Via Carlo Magno 1A
Town : Parma
NUTS-Code : ITH52 - Parma
Postal Code : 43126
Email :efsaprocurement@efsa.europa.eu
URL :https://etendering.ted.europa.eu/general/page.html?name=home&locale=en
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